PENGARUH PROTEKSI VITAMIN E TERHADAP KADAR UREUM DAN KREATININ MENCIT (MUS MUSCULUS) YANG DI PAPAR PLUMBUM

PENGARUH PROTEKSI VITAMIN E TERHADAP KADAR UREUM DAN KREATININ MENCIT (MUS MUSCULUS) YANG DI PAPAR PLUMBUM

VITAMINS - APPLIED NUTRITION

Plumbum poisoning has become a public health problem in the world.Vitamin E is an antioxidant compound that allergedly reduces cytotoxityplumbum. The purpose of this study was to determine the effect of vitamin E inmice exposed plumbum. This study is a laboratory experimental research whichused a complete random design. In this study, vitamin E was given orallyeveryday for 7 days. Then plumbum was given intraperitoneally two hours aftervitamin E. Examination of urea and creatinine was done 2 days after. There were5 groups in this research, such as: Group I (aquadest), Group II (20 mg /KgBWplumbum), Group III (200 mg / KgBW Vitamin E + 20 mg / kgBW Plumbum),Group IV (500 mg / KgBW vitamin E + 20 mg / KgBW plumbum),Group V (1000 mg / KgBW vitamin E + 20 mg / KgBW plumbum). The results ofthis study indicated that there is no significant effect ofvitamin E protection against Plumbum. This may be caused by a lackof high doses of vitamin E that was given so that the protection that causedwas less effective. The conclusion of this study is vitamin E does not provideeffective protection against plumbum exposure.Keywords : Plumbum, Vitamin E, Urea and creatine

Banda Aceh

Dimas Arya Umara

Fakultas Kedokteran

2011

SKR

id

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