Rat psychomotor development and apoptotic protein expression in their brains after glucocorticoid treatment

Rat psychomotor development and apoptotic protein expression in their brains after glucocorticoid treatment

A single injection of low-dose dexamethasone on postnatal day 3 resulted in the upregulation of key apoptotic enzyme – active caspase-3 in the rat cortex 120 hours after injection, and was followed by a delayed development of neonatal startle reflex and cliff avoidance reaction, an arrest of body weight gain and reduced spontaneous locomotor activity of pups. A single hydrocortisone administration to neonatal rats was only followed by a short-term delay in body weight gain, with no changes in the levels of active caspase-3 in the cortex and brainstem, as well as with no abnormalities in neurodevelopment. These results evidence for lesser neurotoxicity of natural hormone during neonatal development in comparison with dexamethasone and suggest the possibility that hydrocortisone might be used as a substitution for its synthetic analogue in the perinatal medicine

Menshanov, Petr N.; Functional Neurogenomics Laboratory, Institute of Cytology and Genetics SB RAS, Russian Academy of Science, Novosibirsk 630090, Russian Federation

Bannova, Anita V.

Dygalo, Nikolay N.; Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russian Federation

Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter; Vol 2, No 1 (2012): Life Sciences

2089-208X

Syiah Kuala University

2012-11-30

http://jurnal.unsyiah.ac.id/AICS-SciEng/article/view/1783/1680

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Peer-reviewed Article

http://jurnal.unsyiah.ac.id/AICS-SciEng/article/view/1783