The isolation and identification of antimalarial agents of the n-hexane fraction of the neem leaves (Azadirachta indica A. Juss)

The isolation and identification of antimalarial agents of the n-hexane fraction of the neem leaves (Azadirachta indica A. Juss)

 Abstract. Following the study which confirmed the antimalarial activity of the n-hexane fraction of the neem leaves (Azadirachta indica A.Juss), a research that aimed to reveal the active compounds act as antimalarial agents had been conducted. In this study, the n-hexane fraction of neem leaves were analyzed using the phytochemical, spectroscopic and chromatographic methods.  The chemical compounds, suspected to have an antimalarial activity, were isolated using the thin-layer chromatographic method with several solvents which different in their polarity. The visualizing reagents were used to characterize the compounds. The result showed that the n-hexane fraction of neem leaves contained of steroids, terpenoids and fenols. Analysis by gas chromatography-mass spectroscopy showed that fenol derivatives existed in the largest amount. The compounds were identified as benzyl benzoat (25.63%), tetracosane (17.51%) and hexadecanal (14.61%)

Suryawati, .

Yusuf, Hanifah

Sofia, .

Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter; Vol 1, No 1 (2011): Life Sciences

2089-208X

Syiah Kuala University

2011-12-15

http://jurnal.unsyiah.ac.id/AICS-SciEng/article/view/1937/1875

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eng

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Peer-reviewed Article

http://jurnal.unsyiah.ac.id/AICS-SciEng/article/view/1937