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                <text>ABSTRAKUji aktivitas ekstrak metanol daun Annona muricata L. telah dilakukan terhadap larva nyamuk Culex sp. Konsentrasi larutan uji adalah 2000; 1000; 500; 250; 125; 62,5; dan 31,25 ppm. Kontrol positif menggunakan abate pada 100 ppm dan kontrol negatif menggunakan akuades. Ekstraksi dilakukan dengan cara maserasi sampel dalam pelarut metanol. Aktivitas larvasida dilakukan dengan menghitung jumlah larva nyamuk Culex sp. yang mati setelah perlakuan selama 12 jam dengan interval pengamatan setiap 2 jam. Aktivitas larvasida ekstrak daun A. muricata L. dalam mematikan serangga uji dihitung dengan menggunakan analisa probit untuk mendapatkan LC50 dan LT50 untuk 12 jam. Hasil analisa probit diperoleh LC50 dan LT50 ekstrak daun A. muricata L. sebesar 442,59 ppm dan 2 jam pada konsentrasi 2000 ppm  dengan tingkat mortalitas 5,47 %. Data tersebut menunjukkan bahwa ekstrak metanol daun A. muricata L. aktif sebagai larvasida terhadap larva nyamuk Culex sp. Kata kunci : Annona muricata L., Larvasida, Culex spABSTRACTActivity of the methanol extract of leaves of Annona muricata L. against mosquito larvae of Culex sp. have been done. The concentration of the test solution is 2000; 1000; 500; 250; 125; 62,5; and 31,25 ppm. Positive control using abate at 100 ppm and negative controls using distilled water. Extraction is done by maceration of samples in methanol. Larvicidal activity carried out by counting the number of larvae of the mosquito Culex sp. who died after treatment for 12 hours at intervals of every 2 hours of observation. Larvicidal activity of the leaf extract of A. muricata L. the test insects deadly calculated using probit analysis to obtain LC50 and LT50 for 12 hours. Probit analysis results obtained LC50 and LT50 extract of leaves of A. muricata L. amounted to 442,59 ppm and 2 hours at a concentration of 2000 ppm with a level of 5,47% mortality. The data showed that the methanol extract of leaves of A. muricata L. active as larvicides against mosquito larvae of Culex sp.Keywords : Annona muricata L. , Larvicides , Culex sp</text>
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                <text>ABSTRAKUji aktivitas ekstrak metanol daun Annona muricata L. telah dilakukan terhadap larva nyamuk Culex sp. Konsentrasi larutan uji adalah 2000; 1000; 500; 250; 125; 62,5; dan 31,25 ppm. Kontrol positif menggunakan abate pada 100 ppm dan kontrol negatif menggunakan akuades. Ekstraksi dilakukan dengan cara maserasi sampel dalam pelarut metanol. Aktivitas larvasida dilakukan dengan menghitung jumlah larva nyamuk Culex sp. yang mati setelah perlakuan selama 12 jam dengan interval pengamatan setiap 2 jam. Aktivitas larvasida ekstrak daun A. muricata L. dalam mematikan serangga uji dihitung dengan menggunakan analisa probit untuk mendapatkan LC50 dan LT50 untuk 12 jam. Hasil analisa probit diperoleh LC50 dan LT50 ekstrak daun A. muricata L. sebesar 442,59 ppm dan 2 jam pada konsentrasi 2000 ppm  dengan tingkat mortalitas 5,47 %. Data tersebut menunjukkan bahwa ekstrak metanol daun A. muricata L. aktif sebagai larvasida terhadap larva nyamuk Culex sp. Kata kunci : Annona muricata L., Larvasida, Culex spABSTRACTActivity of the methanol extract of leaves of Annona muricata L. against mosquito larvae of Culex sp. have been done. The concentration of the test solution is 2000; 1000; 500; 250; 125; 62,5; and 31,25 ppm. Positive control using abate at 100 ppm and negative controls using distilled water. Extraction is done by maceration of samples in methanol. Larvicidal activity carried out by counting the number of larvae of the mosquito Culex sp. who died after treatment for 12 hours at intervals of every 2 hours of observation. Larvicidal activity of the leaf extract of A. muricata L. the test insects deadly calculated using probit analysis to obtain LC50 and LT50 for 12 hours. Probit analysis results obtained LC50 and LT50 extract of leaves of A. muricata L. amounted to 442,59 ppm and 2 hours at a concentration of 2000 ppm with a level of 5,47% mortality. The data showed that the methanol extract of leaves of A. muricata L. active as larvicides against mosquito larvae of Culex sp.Keywords : Annona muricata L. , Larvicides , Culex sp</text>
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                <text>ABSTRAKUji aktivitas ekstrak metanol daun Annona muricata L. telah dilakukan terhadap larva nyamuk Culex sp. Konsentrasi larutan uji adalah 2000; 1000; 500; 250; 125; 62,5; dan 31,25 ppm. Kontrol positif menggunakan abate pada 100 ppm dan kontrol negatif menggunakan akuades. Ekstraksi dilakukan dengan cara maserasi sampel dalam pelarut metanol. Aktivitas larvasida dilakukan dengan menghitung jumlah larva nyamuk Culex sp. yang mati setelah perlakuan selama 12 jam dengan interval pengamatan setiap 2 jam. Aktivitas larvasida ekstrak daun A. muricata L. dalam mematikan serangga uji dihitung dengan menggunakan analisa probit untuk mendapatkan LC50 dan LT50 untuk 12 jam. Hasil analisa probit diperoleh LC50 dan LT50 ekstrak daun A. muricata L. sebesar 442,59 ppm dan 2 jam pada konsentrasi 2000 ppm  dengan tingkat mortalitas 5,47 %. Data tersebut menunjukkan bahwa ekstrak metanol daun A. muricata L. aktif sebagai larvasida terhadap larva nyamuk Culex sp. Kata kunci : Annona muricata L., Larvasida, Culex spABSTRACTActivity of the methanol extract of leaves of Annona muricata L. against mosquito larvae of Culex sp. have been done. The concentration of the test solution is 2000; 1000; 500; 250; 125; 62,5; and 31,25 ppm. Positive control using abate at 100 ppm and negative controls using distilled water. Extraction is done by maceration of samples in methanol. Larvicidal activity carried out by counting the number of larvae of the mosquito Culex sp. who died after treatment for 12 hours at intervals of every 2 hours of observation. Larvicidal activity of the leaf extract of A. muricata L. the test insects deadly calculated using probit analysis to obtain LC50 and LT50 for 12 hours. Probit analysis results obtained LC50 and LT50 extract of leaves of A. muricata L. amounted to 442,59 ppm and 2 hours at a concentration of 2000 ppm with a level of 5,47% mortality. The data showed that the methanol extract of leaves of A. muricata L. active as larvicides against mosquito larvae of Culex sp.Keywords : Annona muricata L. , Larvicides , Culex sp</text>
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                <text>ABSTRAKKata kunci: Aktivitas Protease, Karakterisasi pH, Actinomycetes.Penelitian Uji Aktivitas Protease dan Karakterisasi pH Actinomycetes Isolat ATH-03 Asal Tahura Pocut Meurah Intan Kabupaten Aceh Besar telah dilaksanakan sejak tanggal 3 September sampai dengan 27 Desember 2012. Penelitian ini bertujuan untuk mengukur aktivitas protease dan mengetahui pH optimum aktivitas protease dari isolat Actinomycetes ATH-03. Metode penelitian yang digunakan adalah metode Eksperimen dengan Rancangan Acak Lengkap Non Faktorial dengan 6 kali perlakuan, 2 kali ulangan. Data yang diperoleh dianalisis secara deskriptif yang terkait dengan nilai indeks proteolitik sebagai dasar seleksi isolat Actinomycetes. Isolat Actinomycetes berasal dari koleksi Laboratorium Mikrobiologi Jurusan Biologi FMIPA Universitas Syiah Kuala. Delapan belas isolat Actinomycetes menunjukkan aktivitas pada Media NA yang mengandung susu skim 1%. Isolat ATH-03 dipilih dalam penelitian ini karena memiliki zona bening yang lebar dengan indeks proteolitik (IP) tertinggi 8,537 setelah inkubasi selama 48 jam pada Media NAS. Protease ekstraseluler dikarakterisasi menggunakan media NB yang mengandung susu skim 1% sebagai media produksi. Waktu optimum pemanenan ekstrak kasar protease isolat ATH-03 pada hari ke-7 dengan aktivitas sebesar 0,083 U/ml, kadar protein 0,003 mg/ml dan aktivitas spesifik mencapai 23,72 U/mg. Hasil karakterisasi pH ekstrak kasar enzim isolat ATH-03 menunjukkan aktivitas optimum pada pH 8 yaitu 0,067 U/ml, protease yang dihasilkan oleh isolat ini aktif  pada kisaran pH netral.</text>
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                <text>Rizky Nurismi</text>
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                <text>http://etd.unsyiah.ac.id//index.php?p=show_detail&amp;id=15019</text>
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                <text>UJI AKTIVITAS SALEP EKSTRAK ETANOL BIJI PINANG (ARECA CATECHU L.) TERHADAP PENYEMBUHAN LUKA PADA RNMENCIT (MUS MUSCULUS ALBINUS)</text>
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                  <text>ETD USK</text>
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          <element elementId="39">
            <name>Creator</name>
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                <text>Ega Rizki</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Uji aktivitas senyawa antibakteri ekstrak n-heksana dari daun Ketepeng Cina (Cassia alata) telah dilakukan. Daun C. alata dimaserasi dengan pelarut n-heksana diperoleh ekstrak n-heksana 31,79 g (3,97%). Ekstrak n-heksana daun C. alata dipisahkan komponen-komponenya dengan kromatografi cair vakum, didapatkan 7 fraksi masing-masing adalah fraksi A(4,83 g), fraksi B( 5,18 g), fraksi C(1,46 g), fraksi D(1,86 g), fraksi E(2,08 g), fraksi F(0,81 g) dan fraksi G(0,67 g). Ekstrak kasar dan fraksi-fraksi yang diperoleh diuji aktivitas antibakteri  terhadap bakteri Escherichia coli dan Staphylococcus aureus menggunakan metode difusi agar dengan konsentrasi 5, 10 dan 20%. Kontrol positif yang digunakan kloramfenikol. Fraksi yang paling aktif terhadap bakteri uji adalah fraksi G dengan konsentrasi 20% zona hambat yang dihasilkan pada bakteri E.coli sebesar 8,3 dan 20 mm terhadap bakteri S. aureus. Berdasarkan hasil uji fitokimia, fraksi G memiliki kandungan metabolit sekunder golongan steroid yang diduga aktif terhadap bakteri E. coli dan S. aureus.Kata Kunci : Ketepeng Cina (Cassia alata), antibakteri, ekstrak n-heksana, metabolit sekunder.</text>
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                <text>http://etd.unsyiah.ac.id//index.php?p=show_detail&amp;id=3393</text>
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            <description>A name given to the resource</description>
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              <elementText elementTextId="40516">
                <text>UJI AKTIVITAS SENYAWA ANTIBAKTERI EKSTRAK n-HEKSANA DAUN KETEPENG CINA (Cassia alata)</text>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="57231">
                <text>Rohaya Afrida</text>
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            <description>An account of the resource</description>
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                <text>ABSTRAKPenelitian ini bertujuan untuk mengetahui aktivitas sitotoksik ekstrak n-heksana, etilasetat dan metanol daun tumbuhan biduri (Calotropis gigantea) terhadap Artemiasalina dengan metode Brine shrimp. Daun biduri dimaserasi menggunakan pelarutn-heksana, etil asetat dan metanol sehingga diperoleh rendemen berturut-turut 1,16%,1,10% dan 4,22%. Ekstrak etil asetat selanjutnya dipisahkan dengan kromatografikolom cair vakum, sehingga diperoleh tiga fraksi gabungan yaitu fraksi I, II dan III.Hasil uji fitokimia menunjukkan ekstrak kasar dan fraksi-fraksi ekstrak etil asetatdaun biduri mengandung senyawa metabolit sekunder golongan alkaloid, terpenoid,fenol dan kumarin. Hasil uji aktivitas sitotoksik menunjukkan ekstrak etil asetatmemiliki aktivitas sitotoksik lebih besar dibandingkan ekstrak n-heksana dan metanoldengan nilai LC50 masing-masing sebesar 109,69 ?g/mL, 63,70 ?g/mL dan 110,89?g/mL sedangkan untuk fraksi I dan fraksi II adalah 163,26 dan 182,89 ?g/mL.Kata Kunci: Calotropis gigantea, Artemia salina, aktivitas sitotoksik.ABSTRACTThis study was intended to find out the cytotoxic activity extracts of n-hexane, ethylacetate and methanol of Calatropis gigantea leaves against Artemia salina by usingBrine shrimp lethality test (BSLT) method. C. gigantea leaves was macerated usingthe solvents n-hexane, ethyl acetate and methanol in order to obtain yield 1.16% ,1.19% and 4.22% respectively. The ethyl acetate extract was separated by usingvacuum liquid column chromatography and obtained three combined of fractions,namely fraction I, II and III. Phytochemical test results showed the crude extract andfractions of ethyl acetate extract of C. gigantea leaves containing secondarymetabolites such as alkaloids, terpenoids, phenols and coumarins. The BSLT resultsshowed cytotoxic activity of ethyl acetate extract had greatest compare to n-hexaneand methanol extracts with LC50 value 63.70, 109.69 and 110.89 ?g/mL, while forfractions I and II were 163.26 and 182.89 ?g/mL respectively.Keywords: Calatropis gigantea, Artemia salina, cytotoxic activity.</text>
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              <elementText elementTextId="57235">
                <text>http://etd.unsyiah.ac.id//index.php?p=show_detail&amp;id=5135</text>
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              <elementText elementTextId="57237">
                <text>UJI AKTIVITAS SITOTOKSIK EKSTRAK DAUN TUMBUHAN BIDURI (CALOTROPIS GIGANTEA )</text>
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            <name>Creator</name>
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                <text>cut rita dahlia</text>
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            <description>An account of the resource</description>
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                <text>ABSTRAKPenelitian ini bertujuan untukmenguji aktivitas sitotoksik ekstrak kulit akar tumbuhan biduri menggunakan metode Brine Shrimp Lethality Test (BSLT) dan fraksinasi menggunakan metode kromatografi kolom cair vakum (KKCV). Pengujian aktivitas sitotoksik dilakukan terhadap semua ekstrak dan fraksi gabungan dari hasil fraksinasi ekstrak etil asetat. Hasil ekstraksi kulit akar tumbuhan biduri(5,3 kg) menggunakan pelarut metanol menghasilkan ekstrak metanol sebanyak 73,04 g. Hasil partisi menggunakan pelarut n-heksan dan etil asetat menghasilkan ekstrak pekat n-heksan dan etil asetat masing-masing sebanyak 19,2 g dan 27,73 g, sedangkan ekstrak pekat metanol diperoleh sebanyak 24,67 g. Hasil uji fitokimia akar segar, ekstrak dan fraksi gabungan positif mengandung metabolit sekundersaponin, kumarin dan terpenoid. Hasil uji aktivitas sitotoksik terhadap larva Artemia salina menghasilkan nilai LC50 sebesar63,82 ppm untuk ekstrak metanol, 36,79ppm untuk ekstrak etil asetat dan 72,84ppm untuk ekstrak n-heksan. Nilai LC50 fraksi gabungan A-F masing-masing yaitu 593,82ppm, 595,88ppm, 20,29ppm, 18,94ppm, 31,61ppm dan 94,35ppm. Kontrol positif (vinkristin sulfat) mempunyai nilai LC50 sebesar 0,21 ppm.Kata Kunci: Biduri, BSLT, sitotoksik, Artemia salinaABSTRACTThis study was conducted to examine thecytotoxicactivity ofC. gigantearoot barkextract by usingBrine ShrimpLethality Test(BSLT)andfractionation usingvacuumliquidcolumn chromatography.The cytotoxic activity assay was performed to all extract and combined of fractions from the ethyl acetate extract. The methanolextracts from C. gigantea root bark extraction by usingmethanol solvent was 73.04 g.From the partition using n-hexane and ethyl acetate as the  solvents we obtained 19.2 g and 27.73 g extracts, while asthe concentrated methanol extract results in 24.67 g. From the phytochemical test of fresh root, extract and combined fractions, we obtained positive results of secondary metabolites such as saponins, coumarins and terpenoids. The cytotoxic activity assay against Artemia salina larvae resulted in LC50 values of 63.82 ppm for methanol extract, 36.79 ppm for ethyl acetate extract and 72.84 ppm forn-hexane extract.LC50 values of  combined  fractionsA, B, C, D and F were 593.82, 595.88, 20.29, 18.94, 31.61 and 94.35 ppm respectively and  positive control (vincristine sulphate) has LC50 value of 0.21 ppm.Keyword:C. gigantea, BSLT, cytotoxic, Artemia salina</text>
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                <text>http://etd.unsyiah.ac.id//index.php?p=show_detail&amp;id=5089</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="56679">
                <text>UJI AKTIVITAS SITOTOKSIK EKSTRAK KULIT AKAR TUMBUHAN BIDURI (C. GIGANTEA)</text>
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